South Korea’s most talked-about skin treatment has arrived, and it is not a serum, a peel, or a laser. It is salmon DNA, and it is quietly becoming one of the most searched skincare treatments in the world.
If you have been seeing “Rejuran” or “Salmon DNA Facial” everywhere and wondering whether there is real science behind the trend, this is everything you need to know.
At The Velvet Skin Centre, with clinics in Indira Nagar and Thakurganj, Lucknow, patients receive personalized skin rejuvenation plans under the guidance of Dr. Asma Parveen (MD Dermatology), a dermatologist with over 14 years of experience and 5000+ patients treated. Every treatment recommendation is based on a detailed skin assessment, individual concerns, and realistic expectations regarding outcomes.
While Salmon DNA Facial has gained global attention for its regenerative approach to skin rejuvenation, understanding how it works, who may benefit, and what results can realistically be expected is essential before considering treatment.
What Is a Salmon DNA Facial (Rejuran)?
A Salmon DNA Facial, clinically known as Rejuran, is a skin bioregenerator treatment that uses purified DNA fragments derived from salmon, called PolyNucleotides (PN) and PolyDeoxyRiboNucleotides (PDRN), to stimulate skin regeneration from within. It originated in South Korea, where it has been the number one skin booster treatment for several years, and has since gained global recognition for its ability to repair, hydrate and visibly rejuvenate skin at a cellular level.Â
Unlike facials that work purely on the surface, Rejuran delivers bioactive DNA molecules into the deeper layers of the skin, where they support collagen production, restore skin elasticity, and accelerate the skin’s natural healing process.Â
According to Pharmaresearch Co., Ltd., the South Korean manufacturer behind Rejuran, the treatment has been clinically validated across multiple peer-reviewed studies for its ability to improve skin elasticity, hydration and overall skin quality.Â
How Salmon DNA Works in Human Skin
Salmon share a 97% genetic similarity with humans. The DNA fragments extracted from salmon, specifically from salmon milt, are structurally compatible with human skin at a cellular level. When purified and processed into small enough molecules, these fragments penetrate the dermis and communicate directly with skin cells, triggering repair and regeneration processes that the skin cannot achieve as efficiently on its own.
The active ingredients, PN and PDRN, are not foreign chemicals. They are biological building blocks that your skin already recognises and responds to, which is why the treatment has an exceptionally low risk of adverse reactions and suits virtually all skin types and tones.
What Skin Concerns Does Rejuran Treat?
Rejuran is clinically popular because it addresses multiple skin concerns at the same time instead of targeting only one issue.Â
Skin Concern | How Rejuran Helps |
Fine lines and early wrinkle | Stimulates collagen and elastin to smooth and firm |
Loss of skin elasticity | Rebuilds structural integrity at a cellular level |
Dull or dehydrated skin | Restores deep hydration and luminosity |
Enlarged pores and uneven texture | Refines skin surface through cellular regeneration |
Post-acne scarring | Accelerates repair of damaged tissue |
Hyperpigmentation and uneven tone | Supports skin renewal and fades discolouration |
Thinning skin from ageing or sun damage | Increases fibroblast activity to restore skin density |
Because it works at the cellular level rather than on the surface, the results tend to be more natural, progressive, and longer-lasting than most topical treatments.Â
How Does Salmon DNA Facial Work?Â
The treatment is delivered in one of two ways, depending on the clinic and the patient’s goals. Topical ApplicationÂ
The Rejuran solution is applied directly to the skin immediately after a procedure such as microneedling, RF microneedling or laser resurfacing. These treatments create microchannels in the skin that allow the DNA molecules to penetrate significantly deeper than intact skin would permit, dramatically enhancing absorption and results.Â
Injectable Treatment
PDRN is delivered directly into the dermis through fine needles, targeting specific areas of concern with precision. This method is more commonly used in clinical dermatology settings where deeper tissue regeneration is the goal.Â
Both methods trigger the same biological response:Â
- Increased fibroblast activity driving collagen and elastin production â—Ź Accelerated cellular repair and tissue healingÂ
- Improved structural hydration at a dermal levelÂ
- Progressive improvement in skin density, texture and toneÂ
At The Velvet Skin Centre in Lucknow, Dr Asma combines Rejuran with advanced in-clinic procedures to achieve enhanced results. If you are considering complementary treatments, read our guides on Chemical Peels in Lucknow and HydraFacial in Lucknow to understand how these treatments work alongside skin boosters.Â
Salmon DNA Facial Results and TimelineÂ
Rejuran is not an instant result treatment. Because it stimulates your skin’s own regenerative processes, results build progressively over time.Â
Timeline | You Can Expect |
Week 1 to 2 | Improved hydration and skin feel immediately post-treatment |
Week 2 to 3 | Visible improvement in skin texture and brightness |
Week 4 to 6 | Firmer, more elastic skin and reduction in fine lines |
After full course | Significant improvement in overall skin quality, tone and density |
3 to 6 months | Long-term collagen remodelling and sustained results |
Note: Results are cumulative. Each session builds on the last, and most patients describe the overall effect as their skin simply looking better than it has in years, without looking like anything has been done.Â
Is Salmon DNA Facial Safe?
Rejuran has an excellent clinical safety profile. Because the DNA fragments are highly purified and biologically compatible with human skin, adverse reactions are extremely rare.Â
Salmon DNA facial is suitable forÂ
- All skin types and tones, including sensitive skin
- Patients in their late twenties and above with early signs of ageing.Â
- Anyone experiencing post-acne scarring or skin texture damage.Â
- Patients wanting meaningful skin improvement without significant downtime. â—Ź Those looking to complement other in-clinic treatments such as PRP or Fractional CO2 Laser.
Not recommended for:Â
- Pregnant or breastfeeding patients without prior medical clearance.Â
- Patients with active skin infections or open wounds in the treatment area. â—Ź Those with a known allergy to seafood or fish-derived products.
Rejuran vs Hyaluronic Acid Skin Boosters: Key Differences
One of the most common questions patients ask is how Rejuran compares to hyaluronic acid skin boosters such as Profhilo or Juvederm Volite. The distinction is clinically significant.Â
Feature | Rejuran (Salmon DNA) | Hyaluronic Acid Booster |
Primary mechanism | Cellular regeneration and repair | Deep hydration and volumising |
Active ingredient | PN and PDRN (DNA fragments) | Hyaluronic acid |
Collagen stimulation | Direct fibroblast activation | Indirect, through hydration support |
Skin repair | Skin repair Yes, at a structural level | Limited |
Hydration | Yes, as a secondary benefit | Primary benefit |
Best for | Skin quality, texture, scarring, ageing | Immediate plumpness and hydration |
Results timeline | Progressive over weeks | More immediate |
Downtime | Minimal | Minimal |
Many dermatologists now combine Rejuran with hyaluronic acid boosters to deliver both immediate hydration and long-term regeneration simultaneously, making the two treatments highly complementary rather than competitive.Â
According to a peer-reviewed study published in PMC, National Library of Medicine, polynucleotides, including PDRN, have demonstrated measurable improvements in skin elasticity and collagen density across multiple clinical studies, supporting their use as a regenerative treatment in aesthetic dermatology.
How Many Sessions Are Needed for Rejuran?Â
Treatment Phase | Details |
Initial Course | 3 to 4 sessions spaced 3 to 4 weeks apart 1st |
Visible results | 2 to 3 weeks after first session |
Optimal results | 4 to 6 weeks after completing the course |
Maintenance sessions | Every 3 to 6 months |
Duration of results | 6 to 12 months depending on skin condition and lifestyle |
Patients who maintain a consistent skincare routine and daily sun protection consistently report longer-lasting outcomes between sessions.Â
Is Salmon DNA Facial Worth It?
For patients looking for genuine, progressive skin improvement without surgery or significant downtime, Rejuran is one of the most clinically credible options currently available. It is not a trending gimmick. It is backed by over a decade of clinical use in South Korea, where it remains the most recommended skin booster by dermatologists, and its results are well documented across a wide range of skin types and concerns.Â
Quick summary of key benefits:Â
- Stimulates natural collagen and elastin productionÂ
- Improves skin texture, tone and density progressivelyÂ
- Addresses multiple skin concerns simultaneouslyÂ
- Minimal downtime with an excellent safety profileÂ
- Suitable for all skin types, including sensitive skinÂ
- Results that look natural, not treatedÂ
If you have been managing skin concerns such as fine lines, poor texture, acne scarring or overall loss of skin quality and have not found a treatment that delivers lasting, natural-looking results, a Salmon DNA Facial with Rejuran is worth a serious conversation with your dermatologist.Â
Ready to Try Salmon DNA Facial in Lucknow? Book Your Consultation Today
If Rejuran sounds like the right treatment for your skin, the next step is a consultation with Dr. Asma Parveen (MBBS, MD Dermatologist) at The Velvet Skin Centre, Lucknow. She will assess
your skin, confirm whether Rejuran is suited to your specific concerns, and design a protocol that delivers the best possible results for you.Â
Call +91 8002558860 to book your consultation today.
Visit our clinic
Indira Nagar: The Velvet Skin Centre, 23, Amrapali Market, B Block, Indira Nagar, Lucknow, Uttar Pradesh 226016
Thakurganj: The Velvet Skin Centre, Near Ghante Wala Sweets, Thakurganj, Daulatganj, Lucknow, Uttar Pradesh 226003
FAQs
When delivered as a topical application post-microneedling or laser, there is no additional discomfort. When administered as an injectable, a numbing cream is applied beforehand to minimise any sensation. Most patients describe it as very tolerable.Â
Yes. Rejuran works particularly well alongside microneedling, RF microneedling, laser resurfacing, PRP and chemical peels. Dr. Asma at The Velvet Skin Centre will advise on the best combination protocol for your specific skin goals.
Most patients resume normal activities the same day or within 24 hours. Redness and mild swelling at the treatment site typically resolve within 24 to 48 hours.
Thakurganj
Indira Nagar